Optimal combination of early biomarkers for infection and sepsis diagnosis in the emergency department: The BIPS study

Objective : To define the best combination of biomarkers for diagnosis infection and sepsis in emergency room. Methods In this prospective study, consecutive patients with a suspicion room were included. Eighteen different measured plasma, twelve on monocytes, neutrophils, B T-lymphocytes studied combinations determined by gradient tree boosting approach. Results Overall, 291 included analysed, 148 bacterial infection, 47 viral infection. The biomarker which first allowed HLA-DR (human leukocyte antigen DR) MerTk (Myeloid-epithelial-reproductive tyrosine kinase) neutrophils plasma metaloproteinase-8 (MMP8) an area under curve (AUC) = 0.94 [95% confidence interval (IC95): 0.91;0.97]. Among whom was excluded, CD64 expression, CD24 CX3CR1 monocytes ended to AUC 0.98 [0.96;1] those Conclusion convenient cohort admitted two cell surface performant identify